CYTOGENETIC AND INTERPHASE CYTOGENETIC ANALYSES REVEAL CHROMOSOME INSTABILITY BUT NO CLONAL TRISOMY-8 IN DUPUYTREN CONTRACTURE

The results of cytogenetic and FISH analysis performed in 26 cases of Dupuytren contracture are reported. Clonal or sporadic chromosome chan ges were found in 18 cases (69%). Clonal changes consisted of: +2, +16 , -10, -Y, add(1)(p23), del(2)(q21), t(3;16)(p21;q24), add(3)(p24), de l(18)(q21), t(Y;14)(p12;q24), +mar. The results differ from those obta ined in normal palmar fascia used as control, in which -Y and +Y were the only clonal changes found in 2 of 11 analyzed cases (18%). No clon al trisomy 8 was found. FISH analysis performed in 11 cases (centromer ic probe specific for chromosome 8) failed to show the presence of a c ell population with +8. Clonal and sporadic structural changes were di fferent from case to case and no clustering breakpoint was observed. T he significance of the chromosome instability leading to clonal and sp oradic chromosome changes not specific to Dupuytren contracture are di scussed. (C) Elsevier Science Inc., 1997.