MYELODYSPLASTIC SYNDROME WITH BICLONAL MONOSOMY-7 AND TRISOMY-8 AFTERTREATMENT WITH CLADRIBINE (2-CHLORO-2-DEOXYADENOSINE) AND INVOLVED FIELD RADIATION-THERAPY

Therapy-related myelodysplastic syndrome (t-MDS) and acute nonlymphocy tic leukemia (t-ANLL) are dramatic complications of cancer chemotherap y. Drugs like plant alkaloids or antimetabolites have not been reporte d to cause either t-MDS or t-ANLL. Monosomy 7(-7) and trisomy 8 (+8) a re among the most common abnormalities in myelodysplastic syndromes. B oth abnormalities in two different clones of the same patient are very rarely reported. Such a myelodysplastic syndrome occurring shortly af ter treatment with an antimetabolite, the adenosine analogue cladribin e (1-chlorodeoxadenosine), and involved field radiotherapy is reported here. (C) Elsevier Science Inc., 1997.