Jl. Charlton et Ka. Lee, THOMASIDIOIC ACID AND 6-HYDROXY-5,7-DIMETHOXY-2-NAPHTHOIC ACID - ARE THEY REALLY NATURAL-PRODUCTS, Tetrahedron letters, 38(42), 1997, pp. 7311-7312
It has been shown that air oxidation of alkaline aqueous solutions of
sinapic acid produces both thomasidioic acid (1), and 6-hydroxy-5,7-di
methoxy-2-naphthoic acid (2) in high yield, with the relative amounts
dependent on the basicity of the solution. It has also been shown that
naphthoic acid 2 is a secondary oxidation product of thomasidioic aci
d, a reaction that also produces 2,6-dimethoxy-p-benzoquione (3). The
question of whether compounds 1, 2 and 3 are really natural products,
as previously reported, is discussed. (C) 1997 Elsevier Science Ltd.