POLYKETIDE LIBRARY SYNTHESIS - ITERATIVE ASSEMBLY OF EXTENDED POLYPROPIONATES USING (R)-1-(BENZYLOXY)-2-METHYLPENTAN-3-ONE AND (S)-1-(BENZYLOXY)-2-METHYLPENTAN-3-ONE

Authors
PATERSON I SCOTT JP
Citation
I. Paterson et Jp. Scott, POLYKETIDE LIBRARY SYNTHESIS - ITERATIVE ASSEMBLY OF EXTENDED POLYPROPIONATES USING (R)-1-(BENZYLOXY)-2-METHYLPENTAN-3-ONE AND (S)-1-(BENZYLOXY)-2-METHYLPENTAN-3-ONE, Tetrahedron letters, 38(42), 1997, pp. 7441-7444
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
42
Year of publication
1997
Pages
7441 - 7444
Database
ISI
SICI code
0040-4039(1997)38:42<7441:PLS-IA>2.0.ZU;2-4
Abstract
The heptapropionates 5 and 20 were synthesised by iterative applicatio n of the boron-mediated aldol reaction of ethyl ketone (R)-4 and subse quent reduction. Polyketide library diversification was realised by va rying the ketone configuration and substitution in the aldol bond cons tructions. (C) 1997 Elsevier Science Ltd.