CASPASES AND CASPASE INHIBITORS

Authors
VILLA P KAUFMANN SH EARNSHAW WC
Citation
P. Villa et al., CASPASES AND CASPASE INHIBITORS, Trends in biochemical sciences, 22(10), 1997, pp. 388-393
Citations number
78
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
22
Issue
10
Year of publication
1997
Pages
388 - 393
Database
ISI
SICI code
0968-0004(1997)22:10<388:CACI>2.0.ZU;2-3
Abstract
Five years ago, little was known about mechanisms of apoptotic executi on. Now, one class of cell-death gene, the cysteine aspartases (caspas es) has come under intensive study. This review discusses the two clas ses of caspases, the reasons why humans may have so many caspase genes , the growing list of caspase substrates, and viral and pharmacologica l caspase inhibitors.