A COMPUTER-PROGRAM FOR ANALYSIS, SIMULATION AND OPTIMIZATION OF ASYMMETRIC CATALYTIC PROCESSES PROCEEDING THROUGH 2 CONSECUTIVE STEPS - TYPE-1 - ASYMMETRIZATION-KINETIC RESOLUTIONS

Authors
KROUTIL W KLEEWEIN A FABER K
Citation
W. Kroutil et al., A COMPUTER-PROGRAM FOR ANALYSIS, SIMULATION AND OPTIMIZATION OF ASYMMETRIC CATALYTIC PROCESSES PROCEEDING THROUGH 2 CONSECUTIVE STEPS - TYPE-1 - ASYMMETRIZATION-KINETIC RESOLUTIONS, Tetrahedron : asymmetry, 8(19), 1997, pp. 3251-3261
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
19
Year of publication
1997
Pages
3251 - 3261
Database
ISI
SICI code
0957-4166(1997)8:19<3251:ACFASA>2.0.ZU;2-4
Abstract
A computer program for the treatment of the kinetics of asymmetric cat alytic reactions proceeding through two consecutive steps was develope d. This allows analysis, simulation and optimization of processes cons isting of a sequential (i) asymmetrization of a bifunctional prochiral or meso-compound in a first step, followed by (ii) kinetic resolution of the chiral intermediate in a second step. A case study shows that - provided that the kinetics of both steps are matching - step two may considerably contribute to the asymmetrization reaction. (C) 1997 Els evier Science Ltd.