The results of 67 transjugular liver biopsies are described. Two failu
res were encountered due to inability to pass the needle into acutely
angulated hepatic veins. Thirty-four patients underwent a liver aspira
tion biopsy using a Colapinto needle, while the remainder were biopsie
d using a trucut needle. The success rate with the Colapinto needle wa
s 68% and with the trucut model, 97%. Capsular perforation occurred in
three cases, but without significant morbidity or mortality. It is co
ncluded that the trucut needle biopsy is more reliable than aspiration
biopsy, when the transjugular approach is mandated, in obtaining opti
mal liver tissue for histopathological diagnosis.