Aims-To determine the costs and effectiveness of an anticoagulant nurs
e specialist service compared with a conventional consultant service b
ased on two hospital sites in northwest Hertfordshire. Methods-Sequent
ial design comparing retrospectively the conduct and outcomes of a con
sultant service with a nurse specialist service over two six month per
iods. In each of the six month study periods, all new patients consecu
tively referred for anticoagulation over a three month period (group A
) at the start of each study period and a random selection of patients
who had already been attending the anticoagulant service for one year
or more (group B) were included in the study. Group A patients were f
ollowed for up to three months and group B patients for six months. Th
e main outcome measures were costs of service provision and effectiven
ess. Costs included those far the use of the anticoagulant service, th
ose related to general practitioner (GP) visits and hospitalisations,
and running costs (staff time, laboratory tests, patient transport). M
easures of effectiveness were the mean proportion of time patients spe
nd in the therapeutic range, the number of drugs being taken that coul
d interact adversely and/or inhibit haemostatic function, and patient
and GP satisfaction with service provision. Results-In the consultant
service, for group A there were more patients aged 66-75 years (p = 0.
004) and fewer patients aged more than 76 years (p = 0.001); and for g
roup B, there were fewer patients on anticoagulation for cardiac condi
tions (p = 0.001), but more on anticoagulation for thromboembolic cond
itions (p = 0.02) than in the nurse specialist service. The clinic run
ning costs of the nurse specialist service were pound 4.99 per attenda
nce, compared with pound 4.75 in the consultant service. Including all
other costs related to treatment, there was no statistically signific
ant difference in cost per patient. There was no significant differenc
e is the proportion of time patients spent in the therapeutic range be
tween the consultant service and the nurse specialist service. In the
nurse specialist service, fewer patients in group A were taking drugs
that could interact adversely and/or inhibit haemostatic function (p =
0.01) and more patients were satisfied with service provision (p = 0.
04) compared with the consultant service. There was no significant var
iation in GP satisfaction between the two services. Conclusion-In the
provision of outpatient anticoagulation, the nurse specialist service
was no more expensive than the consultant service and, using our prima
ry outcome, at least as effective. The nurse specialist service has so
me clear advantages compared to the consultant service: provision of d
omicilliary care for house-bound patients, fewer new patients taking d
rugs that could interact adversely and/or inhibit haemostatic function
patients, it is preferred by newly referred patients to the consultan
t service, and it is as acceptable to their GPs.