SYNTHETIC STUDIES OF VITAMIN-D ANALOGS .24. SYNTHESIS OF ACTIVE VITAMIN-D-3 ANALOGS SUBSTITUTED AT THE 2-BETA-POSITION AND THEIR PREVENTIVEEFFECTS ON BONE-MINERAL LOSS IN OVARIECTOMIZED RATS

Authors
ONO Y WATANABE H SHIRAISHI A TAKEDA S HIGUCHI Y SATO K TSUGAWA N OKANO T KOBAYASHI T KUBODERA N
Citation
Y. Ono et al., SYNTHETIC STUDIES OF VITAMIN-D ANALOGS .24. SYNTHESIS OF ACTIVE VITAMIN-D-3 ANALOGS SUBSTITUTED AT THE 2-BETA-POSITION AND THEIR PREVENTIVEEFFECTS ON BONE-MINERAL LOSS IN OVARIECTOMIZED RATS, Chemical and Pharmaceutical Bulletin, 45(10), 1997, pp. 1626-1630
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
10
Year of publication
1997
Pages
1626 - 1630
Database
ISI
SICI code
0009-2363(1997)45:10<1626:SSOVA.>2.0.ZU;2-6
Abstract
Analogs related to 1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitam in D-3 (ED-71) (4), oxa-type and carba-type analogs of vitamin D-3 bea ring substituents at the 2 beta-position of 1 alpha,25-dihydroxyvitami n D-3 (1), were synthesized from the alpha-epoxides (6 and 13), Three analogs, ED-71 (4) and two carba-type analogs (16 acid 26), showed pot ent preventive effects on bone mineral loss in pre-osteoporosis model rats, ED-71 (4) was concluded to be an optimized analog and a promisin g candidate for the treatment of osteoporosis.