DOUBLE ACTIVATION PREPARATION OF AN ACRIDINYL-ISOXAZOLYL-LEXITROPSIN

Authors
ZHOU PW MOSHER MD TAYLOR WD CRAWFORD GA NATALE NR
Citation
Pw. Zhou et al., DOUBLE ACTIVATION PREPARATION OF AN ACRIDINYL-ISOXAZOLYL-LEXITROPSIN, Bioorganic & medicinal chemistry letters, 7(19), 1997, pp. 2455-2456
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
19
Year of publication
1997
Pages
2455 - 2456
Database
ISI
SICI code
0960-894X(1997)7:19<2455:DAPOAA>2.0.ZU;2-G
Abstract
The coupling of a sterically hindered acridinyl isoxazole ester direct ly to the amine group of a lexitropsin is significantly improved by do uble activation, using trimethylaluminum to activate the amine portion and samarium (III) chloride to enhance the carboxylate reactivity. (C ) 1997 Elsevier Science Ltd.