INVESTIGATION INTO THE PREFERRED CONFORMATION OF GABAPENTIN FOR INTERACTION WITH ITS BINDING-SITE ON THE ALPHA(2)DELTA SUBUNIT OF A CALCIUM-CHANNEL

Authors
BRYANS JS DAVIES N GEE NS HORWELL DC KNEEN CO MORRELL AI ONEILL JA RATCLIFFE GS
Citation
Js. Bryans et al., INVESTIGATION INTO THE PREFERRED CONFORMATION OF GABAPENTIN FOR INTERACTION WITH ITS BINDING-SITE ON THE ALPHA(2)DELTA SUBUNIT OF A CALCIUM-CHANNEL, Bioorganic & medicinal chemistry letters, 7(19), 1997, pp. 2481-2484
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
19
Year of publication
1997
Pages
2481 - 2484
Database
ISI
SICI code
0960-894X(1997)7:19<2481:IITPCO>2.0.ZU;2-5
Abstract
A series of conformationally restricted Gabapentin analogues has been synthesised and used to propose the preferred conformation of Gabapent in for it to bind to the alpha(2) delta subunit of a calcium channel. (C) 1997 Elsevier Science Ltd.