SOLID-PHASE SYNTHESIS OF HYBRID THIAZOLIDINEDIONE-FATTY ACID PPAR-GAMMA LIGANDS

Authors
TOMKINSON NCO SEFLER AM PLUNKET KD BLANCHARD SG PARKS DJ WILLSON TM
Citation
Nco. Tomkinson et al., SOLID-PHASE SYNTHESIS OF HYBRID THIAZOLIDINEDIONE-FATTY ACID PPAR-GAMMA LIGANDS, Bioorganic & medicinal chemistry letters, 7(19), 1997, pp. 2491-2496
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
19
Year of publication
1997
Pages
2491 - 2496
Database
ISI
SICI code
0960-894X(1997)7:19<2491:SSOHTA>2.0.ZU;2-G
Abstract
A library of thiazolidinedione-fatty acid hybrid molecules was designe d to probe the relationship between natural and synthetic PPAR ligands . Solid-phase synthesis of the library led to the identification of se veral high affinity PPAR gamma ligands. (C) 1997 Elsevier Science Ltd.