CATALYSIS OF THE KEMP ELIMINATION BY ANTIBODIES ELICITED AGAINST A CATIONIC HAPTEN

Authors
GENREGRANDPIERRE A TELLIER C LOIRAT MJ BLANCHARD D HODGSON DRW HOLLFELDER F KIRBY AJ
Citation
A. Genregrandpierre et al., CATALYSIS OF THE KEMP ELIMINATION BY ANTIBODIES ELICITED AGAINST A CATIONIC HAPTEN, Bioorganic & medicinal chemistry letters, 7(19), 1997, pp. 2497-2502
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
19
Year of publication
1997
Pages
2497 - 2502
Database
ISI
SICI code
0960-894X(1997)7:19<2497:COTKEB>2.0.ZU;2-#
Abstract
Rather efficient catalysis of the decomposition of 5-nitro-benzisoxazo le to the cyanophenol was observed with antibodies elicited against a cationic hapten structurally unrelated to the benzisoxazole substrate. The rate enhancement by the most active antibody is better than 10(4) and the reaction is catalyzed by a carboxylate group associated with a hydrophobic binding site. (C) 1997 Elsevier Science Ltd.