4-BIARYL-SUBSTITUTED DIHYDROPYRIDINES WITH AN UNUSUAL ANTIPERIPLANAR CONFORMATION

Authors
STRAUB A GOEHRT A BORN L
Citation
A. Straub et al., 4-BIARYL-SUBSTITUTED DIHYDROPYRIDINES WITH AN UNUSUAL ANTIPERIPLANAR CONFORMATION, Bioorganic & medicinal chemistry letters, 7(19), 1997, pp. 2519-2522
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
19
Year of publication
1997
Pages
2519 - 2522
Database
ISI
SICI code
0960-894X(1997)7:19<2519:4DWAUA>2.0.ZU;2-1
Abstract
We report X-ray crystal structures and NMR solution data of the unusua l antiperiplanar conformation of 4-dihydro-5-cyano-2,6-dimethyl-4-biar yl-3-pyridine carboxylic acid esters with 3'-(4'-(1 ''- or 2 ''-naphth yl)pyridyl)- and 2'-(9 ''-anthracenyl) phenyl-residues as the biaryl m oiety. This class might serve as a biological tool to identify which D HP-rotamer is responsible for the interaction with the biological rece ptor. (C) 1997 Elsevier Science Ltd.