8'-ACETYLENE ABA - AN IRREVERSIBLE INHIBITOR OF ABA 8'-HYDROXYLASE

Authors
ROSE PA CUTLER AJ IRVINE NM SHAW AC SQUIRES TM LOEWEN MK ABRAMS SR
Citation
Pa. Rose et al., 8'-ACETYLENE ABA - AN IRREVERSIBLE INHIBITOR OF ABA 8'-HYDROXYLASE, Bioorganic & medicinal chemistry letters, 7(19), 1997, pp. 2543-2546
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
19
Year of publication
1997
Pages
2543 - 2546
Database
ISI
SICI code
0960-894X(1997)7:19<2543:8A-AII>2.0.ZU;2-O
Abstract
(+)-8'-Acetylenic ABA has been synthesized through the ligand assisted nucleophilic addition of a Grignard reagent to quinol 6 and is shown to be the first known irreversible inhibitor of ABA 8'-hydroxylase. A series of ABA analogues has been prepared using this procedure. (C) 19 97 Elsevier Science Ltd.