SCH-207278 - A NOVEL FARNESYL-PROTEIN TRANSFERASE INHIBITOR FROM AN UNIDENTIFIED FUNGUS

Authors
CHU M MIERZWA R BARRABEE E KING A HALLADE M TERRACCIANO J PATEL MG PATTON R BISHOP WR PUAR MS
Citation
M. Chu et al., SCH-207278 - A NOVEL FARNESYL-PROTEIN TRANSFERASE INHIBITOR FROM AN UNIDENTIFIED FUNGUS, Bioorganic & medicinal chemistry letters, 7(19), 1997, pp. 2547-2550
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
19
Year of publication
1997
Pages
2547 - 2550
Database
ISI
SICI code
0960-894X(1997)7:19<2547:S-ANFT>2.0.ZU;2-R
Abstract
Novel aromatic dialdehyde, Sch 207278 (1), was isolated from an uniden tified fungus as an inhibitor of farnesyl protein transferase (FPTase) . The structure of 1 was elucidated by spectroscopic methods. Compound 1 exhibited an IC50 value of 3.5 mu M against FPTase and 70 mu M agai nst geranylgeranyl protein transferase-1 (GGPTase-1), respectively. (C ) 1997 Elsevier Science Ltd.