DESIGN, SYNTHESES AND POTENTIATING ACTIVITIES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS OF CYCLIC ANALOGS OF LY301621

Authors
EID CN NICAS TI MULLEN DL LONCHARICH RJ PASCHAL JW
Citation
Cn. Eid et al., DESIGN, SYNTHESES AND POTENTIATING ACTIVITIES AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS OF CYCLIC ANALOGS OF LY301621, Bioorganic & medicinal chemistry letters, 7(16), 1997, pp. 2087-2092
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
16
Year of publication
1997
Pages
2087 - 2092
Database
ISI
SICI code
0960-894X(1997)7:16<2087:DSAPAA>2.0.ZU;2-D
Abstract
Previous SAR studies of the diastereomers of LY301621 suggested the im portance of a beta-turn conformation for biological activity. In the p resent study, cyclic analogs were designed and synthesized that posses s Type II and II' beta-turns. Their biological activity will be discus sed. (C) 1997 Elsevier Science Ltd.