INHIBITION OF HUMAN CYTOMEGALOVIRUS PROTEASE BY BENZOXAZINONES AND EVIDENCE OF ANTIVIRAL ACTIVITY IN CELL-CULTURE

Authors
ABOOD NA SCHRETZMAN LA FLYNN DL HOUSEMAN KA WITTWER AJ DILWORTH VM HIPPENMEYER PJ HOLWERDA BC
Citation
Na. Abood et al., INHIBITION OF HUMAN CYTOMEGALOVIRUS PROTEASE BY BENZOXAZINONES AND EVIDENCE OF ANTIVIRAL ACTIVITY IN CELL-CULTURE, Bioorganic & medicinal chemistry letters, 7(16), 1997, pp. 2105-2108
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
16
Year of publication
1997
Pages
2105 - 2108
Database
ISI
SICI code
0960-894X(1997)7:16<2105:IOHCPB>2.0.ZU;2-M
Abstract
A series of 2-amino substituted benzoxazinones were prepared that pote ntly inhibit human cytomegalovirus protease in vitro. Selected compoun ds demonstrate antiviral activity in cell culture, selectivity relativ e to chymotrypsin and elastase and stability with respect to hydrolysi s in human plasma. (C) 1997 Elsevier Science Ltd.