ABSORPTION BEHAVIOR OF SULPIRIDE DESCRIBED USING WEIBULL FUNCTIONS

Deconvolution absorption profiles of oral sulpiride formulations were calculated from plasma concentration-time data obtained in an open, 3- period study with a crossover of the 2 oral formulations in 12 healthy volunteers following single intravenous (100 mg) and oral (2 x 50 mg capsules, 200 mg tablets) application of sulpiride. A model based on 2 Weibull-functions, and applied using NONMEM, described the complex ab sorption profiles more satisfactorily than a first order absorption mo del or a model based on a single Weibull-function.