IDENTIFICATION AND CHARACTERIZATION OF A MOUSE PROTEIN-KINASE THAT ISHIGHLY HOMOLOGOUS TO HUMAN INTEGRIN-LINKED KINASE

Integrin-linked kinase (ILK) is a recently identified human protein ki nase that has been implicated in integrin-mediated signal transduction and tumorigenesis. We have identified a mouse molecule that is highly homologous to human ILK. The mouse ILK homologue protein is readily r ecognized by antibodies raised against the human ILK protein, and the gene encoding the mouse ILK homologue is widely expressed in mouse tis sues. The mouse ILK homologue gene has been mapped to chromosome 7E1 b and. A second locus in the mouse chromosome 9E1-3 region has also been detected with a mouse ILK homologue cDNA probe by fluorescence in sit u hybridization, suggesting the possible existence of an ILK pseudo-ge ne or a family of ILK genes in the mouse. (C) 1997 Elsevier Science B. V.