BETA(2)-ADRENOCEPTORS ON THE GLIAL-CELLS MEDIATE THE INDUCTION OF INTERLEUKIN-1-BETA MESSENGER-RNA IN THE RAT-BRAIN

Authors
MARUTA E YABUUCHI K NISHIYORI A TAKAMI S MINAMI M SATOH M
Citation
E. Maruta et al., BETA(2)-ADRENOCEPTORS ON THE GLIAL-CELLS MEDIATE THE INDUCTION OF INTERLEUKIN-1-BETA MESSENGER-RNA IN THE RAT-BRAIN, Molecular brain research, 49(1-2), 1997, pp. 291-294
Citations number
11
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
49
Issue
1-2
Year of publication
1997
Pages
291 - 294
Database
ISI
SICI code
0169-328X(1997)49:1-2<291:BOTGMT>2.0.ZU;2-R
Abstract
Interleukin-1 beta mRNA was induced by i.c.v. injection of the beta-ad renoceptor agonist isoproterenol. Lower doses of procaterol, a beta(2) -adrenoceptor agonist showed stronger induction of the mRNA than isopr oterenol. These inductions were primarily observed in the glial cells. On the other hand, the beta(1)-adrenoceptor agonist dobutamine induce d expression of this mRNA only in the meninges. These results suggest the existence of a system for regulation of interleukin-1 beta gene ex pression via beta(2)-adrenoceptors in the brain parenchyma. (C) 1997 E lsevier Science B.V.