STUDIES ON THE SYNTHESIS OF SUBSTITUTED 3,6-DIOXOPERHYDROPYRROLO[1,2-A]PYRAZINES AS NONPEPTIDE SCAFFOLDS FOR PEPTIDOMIMETICS

Authors
MARTINMARTINEZ M GARCIALOPEZ MT HERRANZ R GONZALEZMUNIZ R
Citation
M. Martinmartinez et al., STUDIES ON THE SYNTHESIS OF SUBSTITUTED 3,6-DIOXOPERHYDROPYRROLO[1,2-A]PYRAZINES AS NONPEPTIDE SCAFFOLDS FOR PEPTIDOMIMETICS, Heterocycles, 45(9), 1997, pp. 1723-1732
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
45
Issue
9
Year of publication
1997
Pages
1723 - 1732
Database
ISI
SICI code
0385-5414(1997)45:9<1723:SOTSOS>2.0.ZU;2-D
Abstract
Intramolecular reductive amination of 4-keto diesters, derived from Z- Xaa-Yaa dipeptides, and subsequent gamma-lactamization is a versatile method for the preparation of 3,6-dioxoperhydropyrrolo[1,2-a]pyrazines bearing amino acid side chains at C-1, C-4 and C-7 positions, as Xaa- Yaa-Zaa (Yaa not equal Gly) tripeptide mimetics.