PATIENT-CONTROLLED SEDATION USING PROPOFOL DURING INTERVENTIONAL NEURORADIOLOGIC PROCEDURES

Patient-controlled sedation (PCS) using propofol has been reported to provide safe and effective sedation during a variety of procedures per formed under regional or local anesthesia. in a prospective, randomize d fashion, this study evaluated propofol PCS compared to anesthesiolog ist-administered midazolam-fentanyl sedation during interventional neu roradiologic (INR) procedures. Nineteen patients undergoing 24 INR pro cedures received propofol PCS (PCS dose, 0.5 mg/kg, lockout interval, ? ruin) or anesthesiologist-administered midazolam-fentanyl sedation. Study parameters included discomfort, sedation and anxiety visual anal ogue scores (VAS), cognitive function, patient satisfaction, and compl ications. No difference was found between the two sedation techniques with respect to the levels of sedation and anxiolysis. Cognitive funct ion was well preserved in both groups. Patient satisfaction was simila rly high in both groups. Complications were similar between groups. Th ese included ventilatory depression (two patients in each group) and e xcessive sedation (two patients in each group). Three patients in the propofol group became excessively restless, resulting in brief interru ptions during the respective procedures. Propofol PCS offers a safe se dation technique during INR procedures with a sedation and anxiolysis profile that was not distinguishable from anesthesiologist-administere d midazolam-fentanyl sedation.