CHANGES IN CYCLOSPORINE-A KINETICS AFTER EXPERIMENTAL REDUCTION OF RENAL PARENCHYMA

Authors
SCHUCK O BOHDANECKA M SEDIVY J KRAJICKOVA M CHADIMOVA M MATOUSOVIC K
Citation
O. Schuck et al., CHANGES IN CYCLOSPORINE-A KINETICS AFTER EXPERIMENTAL REDUCTION OF RENAL PARENCHYMA, European journal of drug metabolism and pharmacokinetics, 22(3), 1997, pp. 207-209
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of drug metabolism and pharmacokinetics → ACNP
ISSN journal
03787966
Volume
22
Issue
3
Year of publication
1997
Pages
207 - 209
Database
ISI
SICI code
0378-7966(1997)22:3<207:CICKAE>2.0.ZU;2-#
Abstract
Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral ( intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsible for reduced CyA availability under these conditions have not yet been identified.