TISSUE PLATINUM AFTER CLINICAL TREATMENT WITH CISPLATIN OR CARBOPLATIN IN TUMOR-BEARING PATIENTS

Tissue platinum (Pt) levels were measured in tumor-bearing patients tr eated with either cisplatin or carboplatin. Cisplatin was given by int ra-arterial, intraperitoneal, and intravenous (iv) administrations. Af ter death, vertebrae and intervertebral disks were removed from eight human subjects, and Livers and kidneys were removed from the half of t hem. When cisplatin was administered intraperitoneally, Pt of the live r was higher than that of the kidney, and a high content of Pt was det ected in the vertebra by comparing with the other administration metho ds. At the intra-arterial administration of cisplatin, Pt was mainly a ccumulated in the kidney. At the iv administration of cisplatin, a hig h level of Pt was found in the vertebra and intervertebral disk, espec ially at the highest value at 10.31 mu g/g in the intervertebral disk of one case, whereas a low level of Pt was detected in the Liver. On t he contrary, it was found that the iv administration of carboplatin di d not result in high accumulations of Pt in the liver, kidney, interve rtebral disk, and vertebra. Therefore, Pt is accumulated in different organs, depending on the way cisplatin is administered, but Pt is accu mulated least in them by the administration of carboplatin.