INDIRECT POTENTIOMETRIC DETERMINATION OF CHLORPROMAZINE WITH AN OXIDATIVE COLUMN IN A FLOW-INJECTION SYSTEM

A flow-injection method is proposed for the determination of chlorprom azine and other N-substituted phenothiazines. The procedure is based o n the oxidation of analyte with lead dioxide entrapped into polymeric material in a packed-bed reactor. The oxidation of the drug yields sol uble Pb2+, which is monitored by means of the lead ion selective elect rode in the wall-jet configuration. The calibration graph is linear ov er the range of 0.01 - 2 mu g ml(-1) of chlorpromazine with relative s tandard deviation of 1.4% and sample throughput 20 h(-1). The develope d method was applied to the determination of chlorpromazine in pharmac eutical preparations.