APPLICATION OF AZINE DYES FOR THE DETERMINATION OF RANITIDINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

Utilisation of azine dyes for the development of four simple spectroph otometric methods are described for the determination of Ranitidine hy drochloride (RTH) in pure form and pharmaceutical formulations. Method A is a direct one, which involves the formation of an ion-association complex (lambda(max):600 nm) between the drug molecule and wool fast blue BL. The other three methods, indirect ones, involve the addition of excess oxidant (chloramine-T, for method B; potassium permanganate, for method C, N-bromosuccinimide, for method D) of known concentratio n in acid medium to RTH and the determination of the unreacted oxidant by measurement of the decrease in absorbance of gallocyanine (GC for method B), cresyl fast violet acetate (CFVA for method C) or celestine blue (CB for method D) at a suitable maximum wavelength (lambda(max): 540 nm for methods B&D and lambda(max): 555 nm for method C). The val idities of the methods are tested against the spectrophotometric refer ence method and all are in good agreement.