TIME-DEPENDENT INTERACTIONS BETWEEN IBOGA AGENTS AND COCAINE

The purpose of this study was to clarify the effects of iboga agents o n cocaine-induced hyperactivity. Both inhibition and enhancement of co caine-induced activity by ibogaine have been reported. In the present study rats were treated with either ibogaine (40 mg/kg, i.p.), noribog aine (40 mg/kg, i.p.), 18-methoxycoronaridine (40 mg/kg, i.p.), or sal ine. 1 or 19 h prior to the administration of cocaine (20 mg/kg, i.p.) or saline. Motor activity was monitored thereafter for 3 h. All three iboga agents had acute inhibitory effects and delayed potentiating ef fects on cocaine-induced hyperactivity. These time-dependent effects, which could not be attributed to the motor activity induced by the ibo ga agents alone, account for divergent results reported in the literat ure. (C) 1997 Elsevier Science B.V.