C. Bouaucheau et al., AMINOCARBENE COMPLEXES OF CHROMIUM .8. ACCESS TO THE PYRROLOINDOLE AND PYRROLOCHINOLINE FRAMEWORKS AND SYNTHESIS OF SUBSTITUTED LYCORANES, Journal of organic chemistry, 62(21), 1997, pp. 7247-7259
The use of alkynylaminocarbene complexes of chromium as starting mater
ial for the synthesis of pyrroloindole, pyrrolochinoline, and azaacena
phtylenone skeletons via cascade insertions of alkynes and CO followed
by the rearrangement of zwitterionic intermediates was examined. Both
the precursor complexes, synthesized from the appropriate functionali
zed lactams, as well as their thermolysis products were obtained in sa
tisfactory yields and could be fully characterized. This reaction was
finally applied to the synthesis of substituted lycoranes, a result wh
ich confirmed its general scope.