PREDICTIVE FACTORS FOR LONG-TERM SURVIVAL IN PATIENTS WITH PANCREATIC-CARCINOMA

Background/Aims: Although numerous clinicopathological parameters have been demonstrated to predict the prognosis in patients with pancreati c carcinoma after surgical resection, the factor most significant for their post-operative survival is stilt controversial. Herein, the auth ors have performed histopathological studies on, patients with pancrea tic adenocarcinoma and reviewed their clinical records to detect the m ost significant factor influencing their long term survival. Methodolo gy: We reviewed clinical records and histological findings retrospecti vely. Then we performed univariate and multivariate analyses to find a correlation between the factors and the survival of the patients. Res ults: The overall postoperative morbidity and mortality rates were 30. 0% and 5.6%, respectively. The overall 5-year survival was 9.0%. Univa riate analysis resulted in. the detection of 14 factors which correlat ed with patient prognosis. Multivariate analysis resulted in the detec tion of histologic differentiation, as an. independent predictor for L ongterm survival. Conclusion: Histological differentiation is recommen ded as the most reliable predictor for the prognosis of patients with pancreatic carcinoma after surgical removal.