CDP-DIACYLGLYCEROL SYNTHASE FROM MAMMALIAN-TISSUES

CDP-diacylglycerol resides at the branch point of glycerolipid biosynt hesis as precursor of both the phosphoinositides and phosphatidylglyce rol. The discovery of the phosphoinositide signal transduction pathway and the recognition of its prominent role in intracellular communicat ion has focused new attention on CDP-diacylglycerol synthase. As a rat e-limiting step in this pathway, it is a likely target for regulation. Exploration of this possibility will be facilitated by the recent clo ning of mammalian CDP-DAG synthase. (C) 1997 Elsevier Science B.V.