Li. Vorobyova et al., PATHOGNOMONIC SIGNS OF VIRUS CYTOPATHIC A CTION IN VULVAR LEUKOPLAKIAAND KRAUROSIS PATIENTS, Eksperimental'naa onkologia, 19(3), 1997, pp. 225-230
Data of cytologic and histologic investigation performed in 65 patient
s with kraurosis and vulvar leukoplakia are presented. Pathognomonic c
ellular signs of virus cytopathic action (koilocytotic atypia, binucle
ar cells) were revealed in 32.3% of women; the sings of mild, moderate
, severe epithelial dysplasia were found in bioptates from injured vul
var regions. Various cytomorphologic characteristics of the effect of
antiviral treatment in complex therapy of patients were studied.