INHIBITORY EFFECTS OF CORDIA-SPINESCENS EXTRACTS AND THEIR CONSTITUENTS ON REVERSE-TRANSCRIPTASE AND PROTEASE FROM HUMAN-IMMUNODEFICIENCY-VIRUS

Authors
LIM YA KOJIMA H NAKAMURA N MIYASHIRO H FUSHIMI H KOMATSU K HATTORI M SHIMOTOHNO K GUPTA MP CORREA M
Citation
Ya. Lim et al., INHIBITORY EFFECTS OF CORDIA-SPINESCENS EXTRACTS AND THEIR CONSTITUENTS ON REVERSE-TRANSCRIPTASE AND PROTEASE FROM HUMAN-IMMUNODEFICIENCY-VIRUS, PTR. Phytotherapy research, 11(7), 1997, pp. 490-495
Citations number
15
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
11
Issue
7
Year of publication
1997
Pages
490 - 495
Database
ISI
SICI code
0951-418X(1997)11:7<490:IEOCEA>2.0.ZU;2-T
Abstract
By bioactive-guided fractionation of a water extract of Cordia spinesc ens, magnesium lithospermate (1), calcium rosmarinate (2) and magnesiu m rosmarinate (3) were isolated as patent inhibitory substances agains t HIV-1 reverse transcriptase (RT) with IC50 values of 0.8, 5.8 and 3. 1 mu M, respectively. However, they were weak HIV-1 protease (PR) inhi bitors with IC50>100 mu M. The RT inhibition by these compounds was no ncompetitive with respect to dTTP substrate. (C) 1997 John Wiley & Son s, Ltd.