4 CLASSES OF HERV-K LONG TERMINAL REPEATS AND THEIR ITERATIVE PROMOTER STRENGTHS FOR TRANSCRIPTION

Authors
MOLD DE WU TC ASKIN F HUANG RCC
Citation
De. Mold et al., 4 CLASSES OF HERV-K LONG TERMINAL REPEATS AND THEIR ITERATIVE PROMOTER STRENGTHS FOR TRANSCRIPTION, Journal of biomedical science, 4(2-3), 1997, pp. 78-82
Citations number
27
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Journal of biomedical science → ACNP
ISSN journal
10217770
Volume
4
Issue
2-3
Year of publication
1997
Pages
78 - 82
Database
ISI
SICI code
1021-7770(1997)4:2-3<78:4COHLT>2.0.ZU;2-3
Abstract
The human genome contains abundant copies of HERV-K endogenous retrovi rus sequences. These remnants of ancient infection have the potential to reshape the genome by retrotransposition or infection since they ar e highly expressed in cells of germ line origin. When conserved nucleo tide sequence variations in the U3 region of the HERV-K 3' LTR were us ed to distinguish between individual HERV-K proviruses, 4 major classe s of HERV-K LTRs were identified. HERV-K U3 regions from the different classes were compared in an in vitro transcription assay and were fou nd to vary significantly in their promoter activities.