THE EFFECT OF CHRONIC STRESS ON HEPATIC AND GASTRIC LIPID-PEROXIDATION IN LONG-TERM DEPLETION OF GLUTATHIONE IN RATS

The effect of chronic stress (immobilization and cold) on hepatic and gastric thiobarbituric acid reactive substances (TEARS) and vitamin C levels were investigated in rats having long-term depletion of glutath ione (GSH) by applying buthionine sulfoximine (BSO). GSH and vitamin C levels decreased and TEARS levels increased in the liver and stomach of rats subjected to stress. Long-term BSO administration along with s tress caused no additional changes in these parameters. These results may indicate that long-term glutathione depletion did not potentiate s tress-induced hepatic and gastric lipid peroxidation. (C) 1997 The Ita lian Pharmacological Society.