The present study was performed to examine the effect of varying durat
ion of noise exposure on rat adrenal gland. Animals were exposed to no
ise for 1, 6 and 12 h continuously and the sections obtained from expo
sed rats were compared to those from corresponding controls. No signif
icant ultrastructural changes were found in the zona glomerulosa, whil
e mitochondria of the zona fasciculata showed matrix dilution and cris
tolysis after 1 and 12 h of noise stress, At all exposure times examin
ed, the zona reticularis exhibited areas of diluted cytoplasm, disarra
nged endoplasmic reticulum, membrane vestigia and some altered mitocho
ndria, Diluted cytoplasmic areas appeared in noradrenaline-and adrenal
ine-storing cells after 6 and 12 h of exposure, respectively, Our find
ings indicate that each zona of the adrenal cortex and the two cell ty
pes of adrenal medulla show a differential reaction to noise stress.