P53 ROLE IN DNA-REPAIR AND TUMORIGENESIS

Authors
SODDU S SACCHI A
Citation
S. Soddu et A. Sacchi, P53 ROLE IN DNA-REPAIR AND TUMORIGENESIS, Journal of experimental & clinical cancer research, 16(3), 1997, pp. 237-242
Citations number
22
Categorie Soggetti
Oncology
Journal title
Journal of experimental & clinical cancer research → ACNP
ISSN journal
03929078
Volume
16
Issue
3
Year of publication
1997
Pages
237 - 242
Database
ISI
SICI code
0392-9078(1997)16:3<237:PRIDAT>2.0.ZU;2-7
Abstract
The p53 oncosuppressor is the gene which has been found to be most fre quently altered in human cancers. How the p53 gene contributes to tumo r induction and progression is presently being investigated by numerou s researchers whose specialties range from basic science to clinics. T his is a brief overview of the hypotheses on p53 role in tumorigenesis and the possible use of p53 analyses in tumor prognosis and therapy.