SWITCHING GEARS DURING T-CELL MATURATION - RANTES AND LATE TRANSCRIPTION

Although much is understood about the induction of genes expressed ear ly (within 24 h) after T-cell activation, little is known about the re gulation of expression of genes expressed 'late' (three or more days) post-stimulation. A better understanding of transcriptional regulation at this important stage of T-cell maturation may yield new insights i nto T-cell development and new immunotherapeutic targets.