SPEED CONGENICS - A CLASSIC TECHNIQUE IN THE FAST LANE (RELATIVELY SPEAKING)

Marker-assisted selection protocol (MASP)-based strategies produce con genic strains with the target gene contained on clearly defined donor- derived genomic intervals in less than half the number of generations required by the classic protocol. Thus, the quality and speed of conge nic strain construction are enhanced by this methodology. Here, Edward Wakeland and colleagues compare various MASP-based strategies and dis cuss their advantages with reference to immunological traits.