THE HOST-TUMOR IMMUNE CONFLICT - FROM IMMUNOSUPPRESSION TO RESISTANCEAND DESTRUCTION

A successful immune response against a tumor is dependent on the cytok ine repertoire present at the tumor site. Salem Chouaib and colleagues discuss evidence that, to escape the immune system, tumor cells not o nly produce immunosuppressive cytokines but also employ strategies inv olving altered susceptibility to tumor necrosis factor and Fas cytotox ic pathways and, in some circumstances, use of the Fas ligand to neutr alize effector cells.