CD6-LIGAND INTERACTIONS - A PARADIGM FOR SRCR DOMAIN FUNCTION

Authors
ARUFFO A BOWEN MA PATEL DD HAYNES BF STARLING GC GEBE JA BAJORATH J
Citation
A. Aruffo et al., CD6-LIGAND INTERACTIONS - A PARADIGM FOR SRCR DOMAIN FUNCTION, Immunology today, 18(10), 1997, pp. 498-504
Citations number
44
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
18
Issue
10
Year of publication
1997
Pages
498 - 504
Database
ISI
SICI code
0167-5699(1997)18:10<498:CI-APF>2.0.ZU;2-Z
Abstract
The scavenger receptor cysteine-rich (SRCR) superfamily, which include s proteins expressed by leukocytes, can be subdivided into groups A an d B. Group B contains the lymphocyte cell-surface receptor CD6. This a rticle reviews recent progress in understanding the interaction betwee n CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCA M). Analysis of the CD6-ALCAM interaction may help to understand how o ther SRCR domains bind to their ligands.