BAG-1 INHIBITS P53-INDUCED BUT NOT APOPTIN-INDUCED APOPTOSIS

Citation
Aaam. Danenvanoorschot et al., BAG-1 INHIBITS P53-INDUCED BUT NOT APOPTIN-INDUCED APOPTOSIS, Apoptosis, 2(4), 1997, pp. 395-402
Citations number
44
Categorie Soggetti
Cell Biology",Biology
Journal title
ISSN journal
13608185
Volume
2
Issue
4
Year of publication
1997
Pages
395 - 402
Database
ISI
SICI code
1360-8185(1997)2:4<395:BIPBNA>2.0.ZU;2-5
Abstract
BAG-1 has been identified as a Bet-a-binding protein that inhibits apo ptosis, either alone or in co-operation with Bcl-2. Here we show that BAG-1 inhibits p53-induced apoptosis in the human tumour cell line Sao s-2. In contrast, BAG-1 was unable to inhibit the p53-independent path way induced by apoptin, an apoptosis-inducing protein derived from chi cken anaemia virus. Whereas BAG-1 seemed to co-operate with Bcl-2 to r epress p53-induced apoptosis, co-expression of these proteins had no i nhibitory effect on apoptin-induced apoptosis. Moreover, Bcl-2, and to some extent also BAG-1, paradoxically enhanced the apoptotic activity of apoptin. These results demonstrate that p53 and apoptin induce apo ptosis through independent pathways, which are differentially regulate d by BAG-1 and Bcl-2.