To determine whether postmenopausal bone loss and factors associated w
ith osteoporosis affect tooth retention, we examined vertebral and pro
ximal femoral (postcranial) bone mineral density in relation to tooth
loss and attachment loss in a cross-sectional study of 135 postmenopau
sal women (age range 41-70 yr). Women had at least 10 teeth and no evi
dence of moderate or severe periodontal disease. Full-mouth attachment
loss measurements were made using a pressure-sensitive probe, and bon
e density was determined by dual-energy X-ray absorptiometry. Attachme
nt loss was correlated with tooth loss (number of remaining teeth, rad
iologically determined), but not with vertebral or proximal femur bone
density. Multivariate analysis showed current smoking (p=0.01), years
since menopause (p=0.02) and the interaction of age and current smoki
ng (p<0.01), to be statistically significant predictors of attachment
loss in our study population.