PLASMODIUM FALCIPARUM-SPECIFIC AND MEROZOITE SURFACE PROTEIN 1-SPECIFIC ANTIBODY ISOTYPE BALANCE IN IMMUNE SENEGALESE ADULTS

Authors
NGUER CM DIALLO TO DIOUF A TALL A DIEYE A PERRAUT R GARRAUD O
Citation
Cm. Nguer et al., PLASMODIUM FALCIPARUM-SPECIFIC AND MEROZOITE SURFACE PROTEIN 1-SPECIFIC ANTIBODY ISOTYPE BALANCE IN IMMUNE SENEGALESE ADULTS, Infection and immunity, 65(11), 1997, pp. 4873-4876
Citations number
31
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
11
Year of publication
1997
Pages
4873 - 4876
Database
ISI
SICI code
0019-9567(1997)65:11<4873:PFAMSP>2.0.ZU;2-7
Abstract
This study shows markedly different isotype distributions of antibodie s to asexual blood stages of Plasmodium falciparum and to merozoite su rface protein 1 in clinically immune Senegalese adults depending on th e study site. The relationships between immunoglobulin M (IgM) and IgG and between IgG3 and IgG1 antibodies differed in settings where trans mission is perennial compared to settings where it is seasonal. This s uggests a role for antibody class and/or subclass production and utili zation in the regulation of protective immunity to such antigens.