THE FUNCTIONAL TRANSFORMATION OF CYTOTOXIC LYMPHOCYTES INTO T-SUPPRESSORS UNDER THE INFLUENCE OF 2 MEDIATORS

Authors
ANFALOVA TV GALAKTIONOV VG BRONDZ BD
Citation
Tv. Anfalova et al., THE FUNCTIONAL TRANSFORMATION OF CYTOTOXIC LYMPHOCYTES INTO T-SUPPRESSORS UNDER THE INFLUENCE OF 2 MEDIATORS, Immunology letters, 59(2), 1997, pp. 121-126
Citations number
26
Categorie Soggetti
Immunology
Journal title
Immunology letters → ACNP
ISSN journal
01652478
Volume
59
Issue
2
Year of publication
1997
Pages
121 - 126
Database
ISI
SICI code
0165-2478(1997)59:2<121:TFTOCL>2.0.ZU;2-U
Abstract
A set of CTL-lines in the system differing in the whole H-2 complex: a s well as in distinct subregions of H-2, was established. These lines were routinely tested in Cr-51-release assay to insure that they retai ned lytic activity and antigen-specificity. The result of the interact ion of CTL with H-2K(b)-molecule and alpha(1)-thymosine was transition of CTL into a reversible state of anergy. A high concentration of alp ha(1)-thymosine is necssary for this transition. Anergic CTL caused sp ecific suppressor activity that is functional if transformation of CTL into T-suppressors took place. (C) 1997 Elsevier Science B.V.