M. Shingu et al., ANTIINFLAMMATORY EFFECTS OF RECOMBINANT HUMAN MANGANESE SUPEROXIDE-DISMUTASE ON ADJUVANT ARTHRITIS IN RATS, Rheumatology international, 14(2), 1994, pp. 77-81
The anti-inflammatory effects of recombinant human manganese superoxid
e dismutase on adjuvant arthritis was investigated. Local application
of this manganese superoxide dismutase given every 2 days not only sig
nificantly reduced foot swelling but also retarded radiological bone d
estruction in adjuvant arthritis. Copper zinc superoxide dismutase had
little effect on foot swelling.