ANTIMICROBIAL AND GENOTOXIC ACTIVITIES OF N-HYDROXYALKYL-1,2-BENZISOTHIAZOL-3(2H)-ONE CARBAMIC ESTERS

Authors
CARMELLINO ML PAGANI G TERRENI M PREGNOLATO M BORGNA P PASTONI F ZANI F
Citation
Ml. Carmellino et al., ANTIMICROBIAL AND GENOTOXIC ACTIVITIES OF N-HYDROXYALKYL-1,2-BENZISOTHIAZOL-3(2H)-ONE CARBAMIC ESTERS, Il Farmaco, 52(6-7), 1997, pp. 359-366
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
52
Issue
6-7
Year of publication
1997
Pages
359 - 366
Database
ISI
SICI code
0014-827X(1997)52:6-7<359:AAGAON>2.0.ZU;2-E
Abstract
N-Hydroxyethyl- and N-hydroxypropyl-1,2-benzisothiazol-3(2H) carbamic esters were pre pared in order to test their activity against represen tative bacterial and fungal strains. The obtained results were compare d with those reported for parent alcohols and some interesting conside rations were drawn. None of the studied derivatives possess genotoxic activity in the Bacillus subtilis ice-assay and Salmonella-microsome t est.