ISOSTERES OF CHIRAL CLOFIBRIC ACID ANALOGS - SYNTHESIS, RESOLUTION, ABSOLUTE-CONFIGURATION AND HPLC DETECTION OF THE OPTICAL PURITY

Both racemic and enantiomeric forms of some isosteres of chiral clofib ric acid analogs have been synthesized. Also, the absolute configurati on has been established by chemical cell-elation and the optical purit y determined by a simple HPLC procedure. Moreover, these studies show that the isosteric substitution of the ether oxygen atom of alpha-aryl oxy-alkanoic acids with sulfur, amino and methylene groups lead to com pounds in which both biological activity and stereoselectivity regardi ng chloride channel are highly reduced.