HETEROCYCLES WITH A BENZOTHIADIAZEPINE MOIETY .5. DERIVATIVES OF PYRROLO[2,1-D][1,2,5]BENZOTHIADIAZEPINE, A NOVEL TRICYCLIC RING

The synthesis of pyrrolo[2,1-d][1,2,5]benzothiadiazepin-7(6H)-one 5,5- dioxide has been achieved by reaction between 2-(1H-pyrrol-1-yl)benzen esulfonamide and triphosgene. N-Ethylation of the tricyclic derivative afforded ylpyrrolo[2,1-d][1,2,5]benzothiadiazepin-7(6H)-one 5,5-dioxi de, also obtained by the action of trifosgene on N-ethyl 2-(1H-pyrrol- 1-yl)benzenesulfonamide. Preparation of pyrrole derivatives from 2-ami nobenzenesulfonamide and its N-ethyl derivative by Clauson-Kaas proced ure required preliminary protection of the sulfonamide function.