STUDIES ON ANNELATED 1,4-BENZOTHIAZINES AND 1,5-BENZOTHIAZEPINES .11.SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SEVERAL NAPHTHO-1,4-THIAZINE ANDQUINOLINO-1,4-THIAZINE AND NAPHTHO-1,4-THIAZEPINE AND QUINOLINO-1,4-THIAZEPINE DERIVATIVES CONTAINING THE IMIDAZOLE RING

Several derivatives of naphtho[1,2-b]imidazo[1',2'-d]-1,4-thiazine and -1,4-thiazepine and imidazo[1',2'-4,5]-1,4-thiazino[3,2-c]quinoline a nd -1,4-thiazepino[3,2-c]quinoline have been synthesized. These compou nds and other imidazo[2,1-d][1,5]benzothiazepine derivatives, previous ly synthesized, have been tested for their possible pharmacological ac tivities. One of these substances displayed inhibitory activity on CNS , others showed an appreciable antiinflammatory effect. None of the na phtho and quinolino derivatives showed affinity for the benzodiazepine receptor.